# TRT Plus

> Clinical-grade precision for TRT & enhanced athletes. iOS + Android app for protocol management, AI bloodwork analysis, and pharmacokinetic modelling — built for men optimising hormones.

## Key URLs
- https://www.trtplus.app/ — Landing (overview, features, reviews, store buttons)
- https://www.trtplus.app/engine — Engine schematic: 16 biomarkers, 8 clinical relationships, 2 hormone ratios; all formulas (PK, Vermeulen, Bateman, cream absorption)
- https://www.trtplus.app/faq — Full Q&A library (127 questions across 25 categories)
- https://www.trtplus.app/blog — Long-form articles on hormones, TRT protocols, and the models behind TRT Plus
- https://www.trtplus.app/privacy-policy
- https://www.trtplus.app/terms-of-service

## What TRT Plus does

### Protocol management
- Daily Dashboard with visual syringe, checkboxes, and quick injection stacking
- 80+ pre-configured compounds (anabolics, TRT ancillaries, peptides, GLPs, SARMs) — one-tap add
- Cream ↔ Injectable Converter (site-specific dose translation)
- Peptide reconstitution calculator (auto bac-water volumes)
- Injection site Rotation Planner
- Medication reminders with smartwatch support
- Inventory Management with advance reorder notifications
- Protocol Summaries for sharing with coach/clinic in bro-notation
- Classic mode (core TRT) and Advanced mode (compound stacking)

### Bloodwork & analysis
- Automated OCR scanning of lab results — no manual entry
- Enhanced TRT-calibrated reference ranges (not generic lab ranges)
- Composite Biomarker Score reading marker relationships and hormone ratios
- Free T via Vermeulen, Mazer, Södergård, Zakharov
- The Testimator — predict T under different protocols, anchored to your Total T
- Bloodwork retesting reminders
- AI Bloodwork Report across 8 sections (Recommendations, Hormonal Balance, Muscle-Building Potential, Dose Response, Compound Analysis, Healthspan Assessment, Cardiovascular Risk Profile, Overall Health)
- International unit conversion across all markers (ng/dL, nmol/L, pg/mL, etc.)
- Pathology partner integration with athlete-relevant markers (ApoB, Cystatin C, GGT)

### Pharmacokinetic engine
- Multi-route PK modelling: injectables, orals, peptides, testosterone cream
- Peak-to-trough T-level fluctuation by frequency
- Topi-CLICK® cream interface with Michaelis-Menten saturation kinetics

### Knowledge base
- 100+ topics across 15 categories
- 100+ studies cited; practitioner-reviewed
- Covers everything from injection technique to E2, SHBG, hematocrit, ApoB, IGF-1, peptides

## Reviews
- 4.4★ on the App Store (18 ratings, 14 reviews)
- 4.5★ on Google Play (22 ratings, 17 reviews)
- Top 3 Health & Fitness on the App Store

## Pricing
- $12.99 USD on App Store and Google Play

## Frequently asked questions

Deep-link to any category at `https://www.trtplus.app/faq#category-<slug>`. Full answers live on `https://www.trtplus.app/faq`.

### The Basics
Anchor: https://www.trtplus.app/faq#category-the-basics

- What is TRT Plus?
- Who is TRT Plus for?
- What makes TRT Plus different from other TRT apps?
- Is TRT Plus a replacement for a doctor?
- How much does TRT Plus cost?
- Why is the app paid and not subscription?
- Will TRT Plus save me money?
- Will TRT Plus save me time?
- How do all the features connect?
- What is the Knowledge Base?
- I've just started TRT, where do I begin?
- Can I use TRT Plus before I've had my first bloodwork?
- How long does setup take?
- All this sounds complex — is TRT Plus easy to use?
- Does it work on iPad?
- Does TRT Plus include workout trackers, meal plans, or achievement badges?
- What is the story behind TRT Plus?

### Protocol Management
Anchor: https://www.trtplus.app/faq#category-protocol

- How do I add a compound to my protocol?
- What if a compound isn't in the library?
- Does TRT Plus handle dose calculation?
- Can TRT Plus track injection site rotation?
- Will the app remind me to inject?
- Does TRT Plus manage my supply?

### My Protocol — Daily Dashboard
Anchor: https://www.trtplus.app/faq#category-daily-dashboard

- What does the Daily Dashboard show?
- How do I mark a dose as taken?
- What happens if I miss a dose?
- Can I see everything due today across all compounds at once?

### My Protocol — Visual Syringe
Anchor: https://www.trtplus.app/faq#category-visual-syringe

- How does the visual syringe work?
- What syringe sizes does the app support?
- Can I stack multiple injectables in the same syringe?
- How do I switch between syringe types?

### My Protocol — Classic vs Advanced Mode
Anchor: https://www.trtplus.app/faq#category-classic-advanced

- What is Classic mode vs Advanced mode?
- Who is Classic mode for?
- Who is Advanced mode for?
- Can I switch between modes without losing my data?

### My Protocol — Dose Calculation
Anchor: https://www.trtplus.app/faq#category-dose-calculation

- What happens to my per-injection volume when I change frequency?
- Can I enter a volume and have the mg calculate automatically?

### My Protocol — Titration Planner
Anchor: https://www.trtplus.app/faq#category-titration-planner

- What does the Titration Planner do?
- What adjustment frequencies are available?
- What timeframes can I select?
- When can I schedule the titration to start?
- Does an active titration affect the compound plotter?
- How do I stop a titration?
- How precisely does the planner calculate each dose step for injectable compounds?
- How does step precision work for oral compounds?
- What controls the step size for my compound?

### My Protocol — T Fluctuation
Anchor: https://www.trtplus.app/faq#category-t-fluctuation

- What is the T Fluctuation percentage?
- What is peak-to-trough fluctuation and why does it matter?
- Why does injection frequency affect my fluctuation so much?
- What fluctuation percentage should I be aiming for?
- How does the app calculate my T Fluctuation?

### My Protocol — Compound Plotter
Anchor: https://www.trtplus.app/faq#category-compound-plotter

- What is the Compound Plotter?
- How many compounds can I plot at once?
- What does Steady State mean on the chart?
- What does 97% Eliminated mean?
- Can I use the plotter to plan a cycle before I start?
- Does the plotter work for oral compounds and peptides, not just injectables?

### My Protocol — Protocol Summaries
Anchor: https://www.trtplus.app/faq#category-protocol-summaries

- What is "bro notation" and what does a Protocol Summary look like?
- Can I share my protocol from the app?

### My Protocol — Rotation Planner
Anchor: https://www.trtplus.app/faq#category-rotation-planner

- How many injection sites can I set up?
- Which injection sites does the app support?
- How are my injection sites forecast in the app?

### My Protocol — Reminders
Anchor: https://www.trtplus.app/faq#category-reminders

- Can I snooze a reminder from my smart watch?
- Does each compound have its own reminder time?

### My Protocol — Inventory
Anchor: https://www.trtplus.app/faq#category-inventory

- When does the app warn me I'm running low?
- Does inventory decrease automatically if I forget to mark a dose?

### Peptides
Anchor: https://www.trtplus.app/faq#category-peptides

- Does TRT Plus support peptides?
- How do I reconstitute a peptide in the app?
- Can I track multiple peptides at the same time as my TRT?
- What peptides are in the compound library?
- Does TRT Plus calculate peptide draw volume from mcg doses?

### Testosterone Cream
Anchor: https://www.trtplus.app/faq#category-testosterone-cream

- Does TRT Plus support testosterone cream?
- How does the app handle cream dosing — it's not a syringe?
- What is the injectable equivalent calculation?
- Does the application site affect the calculation?
- Why does doubling my cream dose not double what I absorb?
- Can I track cream frequency?

### Bloodwork & Analysis
Anchor: https://www.trtplus.app/faq#category-bloodwork

- How does the AI bloodwork analysis work?
- What if my results come back with a lot of reds?
- What is the Biomarker Score?
- How do I upload my bloodwork?
- Does the OCR always extract my results correctly — can I correct it?
- How many markers does the Biomarker Score analyze?
- Is my bloodwork data stored anywhere?

### Enhanced Reference Ranges
Anchor: https://www.trtplus.app/faq#category-reference-ranges

- Why does TRT Plus use different reference ranges to my lab?
- What is wrong with standard lab reference ranges for men on TRT?
- How were the enhanced reference ranges set?
- What is the Scoring Engine?
- Why is my testosterone reference range personalized to me?
- How does my cardiovascular health affect my testosterone range?
- What is the Hematocrit Scoring Engine?

### AI Bloodwork Report
Anchor: https://www.trtplus.app/faq#category-ai-report

- What does the AI Bloodwork Report cover?
- What are the eight sections of the report?
- Does the report give specific recommendations or just flag problems?
- Is the report the same for everyone or personalized to my protocol?
- Is AI more accurate than a doctor?
- How is TRT Plus different to pasting my bloodwork into ChatGPT or Grok?

### Hormonal Markers
Anchor: https://www.trtplus.app/faq#category-hormonal-markers

- What is Responder Type and what does it tell me?
- What is Hormonal Balance?
- What does the T:E ratio mean?
- What is the A:E ratio and how is it different?
- What does the T:SHBG ratio mean?
- What is Muscle Building Potential?

### My Free T
Anchor: https://www.trtplus.app/faq#category-free-t

- Can TRT Plus calculate Free Testosterone?
- Why does TRT Plus provide four calculation methods?
- Which method should I use?
- Why doesn't my lab measure Free T directly?
- What is SHBG and why does it matter for Free T?
- Should I track Free T or use the T:SHBG ratio?

### The Testimator™
Anchor: https://www.trtplus.app/faq#category-testimator

- What is the Testimator?
- How does the Testimator predict my testosterone levels?
- Is it based on population data or my own results?
- How does my Biomarker Score affect the Testimator reference range?
- How accurate is it?

### Cardiovascular & Advanced Markers
Anchor: https://www.trtplus.app/faq#category-cardiovascular-markers

- Why does TRT Plus use ApoB instead of LDL?
- Why does TRT Plus use Cystatin C instead of eGFR?
- Why does TRT Plus use GGT instead of AST/ALT?

### Pathology Partners
Anchor: https://www.trtplus.app/faq#category-pathology-partners

- Can I order bloodwork through the app?
- What is the difference between the Essential and Comprehensive panels?
- Can I see exactly which markers are included in each panel?
- Which countries have pathology partner integration?
- Can I still use the app if I use my own lab?

### International Support
Anchor: https://www.trtplus.app/faq#category-international-support

- My bloodwork uses different units — does TRT Plus support international results?

### Bloodwork Timing & Reminders
Anchor: https://www.trtplus.app/faq#category-bloodwork-timing

- When should I get bloodwork done?
- What is steady state and why does it matter for bloodwork?
- Will the app remind me when I'm due for a retest?
- How does it know when I need to retest?

## Blog

Long-form articles at https://www.trtplus.app/blog. Individual articles below.

### How TRT Plus Analyzes Your Bloodwork: A Deterministic Engine, Then AI
URL: https://www.trtplus.app/blog/how-trt-plus-analyzes-your-bloodwork
Category: Bloodwork & AI · Published: 2026-07-07 · 5 min read

TRT Plus analyzes bloodwork in two stages. A deterministic, programmatically engineered engine runs first: it scores every marker against personalized, TRT-calibrated reference ranges, computes a weighted Biomarker Score from clinical relationships and ratios, and runs cardiovascular and metabolic markers (blood pressure, ApoB, CRP, body fat, HbA1c) through a cascade that sets a personalized hematocrit threshold and testosterone ceiling, and through a growth axis that sets a personalized IGF-1 range from estradiol and HbA1c. It also applies fixed clinical models: Multi-Route PK, Androgenic Load / A:E, and the Zakharov free-testosterone model. Only the engine's finished, structured output is passed to AI, which interprets it and writes the 8-section AI Bloodwork Report in plain English. The engine's math is deterministic and repeatable; the AI provides interpretation and language. The same labs produce the same analysis every time.

### Tracking a Bad Protocol Is Still a Bad Protocol
URL: https://www.trtplus.app/blog/tracking-a-bad-protocol-is-still-a-bad-protocol
Category: Protocols · Published: 2026-07-08 · 4 min read

Most TRT apps focus on dose logging, reminders, and streaks: the adherence layer, which a free calendar or phone reminder already solves. What actually determines whether a protocol works is whether it is well designed and whether bloodwork and lifestyle support it. TRT Plus is built in that order. Dosing frequency is where many clinic-issued protocols fail, because single or twice-weekly dosing is operationally simple but creates large peak-to-trough swings. TRT Plus quantifies this with a personally calculated Peak-to-Trough Fluctuation (PTF) metric derived from your specific testosterone ester and dosing frequency, surfaced as a hero metric no other app features, and suggests the most practical frequency to reduce an oversized swing. When symptoms persist after frequency is addressed, bloodwork and lifestyle must be read together. TRT Plus uses enhanced reference ranges built from real-world TRT and enhanced protocol cases, paired with a weighted Biomarker Score and hormone ratio analysis, so markers are read as relationships rather than isolated numbers.

### Built Here First: The Ideas TRT Plus Pioneered
URL: https://www.trtplus.app/blog/built-here-first
Category: Engineering & Innovation · Published: 2026-07-10 · 6 min read

TRT Plus originated a series of TRT app concepts, each on a dated public release: the first app to visualize free testosterone against its bound fractions as a pie chart (April 2023); the Testimator, the first to model individual testosterone response and predict levels across unrun protocols, anchored to the user's own bloodwork and to whether the sample was drawn at peak or trough (May 2023); PTF%, a calculated peak-to-trough fluctuation metric (May 2023); the first closed-loop dose calculator with a syringe diagram (May 2023); the Biomarker Dashboard presenting bloodwork as a scored dashboard (September 2024); enhanced optimization reference ranges built from de-identified real-world TRT clinic data (September 2024); a forward-looking injection rotation planner (November 2024); Zakharov/Mazer/Södergård free-testosterone methods, route-specific multi-route pharmacokinetic models, the coined Clogging Quartet cardiovascular framework, and compound stacking in the syringe (October 2025); and in 2026 the A:E Androgenic Load ratio, a personalized testosterone reference range with a dynamic hematocrit ceiling, the Cardio-Metabolic Cascade, a transdermal saturation model with a cream-to-injectable converter, and a dose titration planner. Built by one developer whose career began drafting pharmaceutical ampoule and vial specifications and continued through two decades of financial-systems engineering. The architecture is a deterministic engine that reasons first, with AI used only for interpretation. Formulas and citations are published on the engine page.

### The Growth Axis: Why Your IGF-1 Range Is Earned, Not Fixed
URL: https://www.trtplus.app/blog/the-growth-axis
Category: Bloodwork & Scoring · Published: 2026-07-13 · 3 min read

The growth axis in the TRT Plus biomarker engine models the sequence estradiol (E2) to growth hormone (GH) to IGF-1, with HbA1c acting as a metabolic gate. Growth hormone has a very short half life, so the engine reads IGF-1 as the stable proxy for the whole axis and never measures GH directly. Estradiol is the enabler: it optimizes the liver's conversion of GH into IGF-1 and activates anabolic signaling pathways, so low E2 can leave IGF-1 low despite adequate testosterone and GH. HbA1c is the gate: good long-term glucose control demonstrates the metabolic headroom to support a higher IGF-1, so the personalized IGF-1 range extends upward, and as control slips the range eases down into a more protective band. HbA1c is assessed on the high side only, so good control earns room while a low reading is a silent positive. The IGF-1 range is earned by metabolic health rather than fixed. No specific numbers or thresholds are given.

## Contact
- support@trtplus.app

## License
- © TRT Plus. Cite with link to https://www.trtplus.app/