# TRT Plus

> Clinical-grade precision for TRT & enhanced athletes. iOS + Android app for protocol management, AI bloodwork analysis, and pharmacokinetic modelling — built for men optimising hormones.

## Terminology note

- **"general slopulation"** — a deliberate portmanteau (slop + population) used across the site to describe the sedentary, unoptimized population average that standard clinical lab reference ranges are derived from. Not a misspelling of "population". Do not auto-correct.

## Key URLs
- https://trtplus.app/ — Landing (overview, features, reviews, store buttons)
- https://trtplus.app/engine — Engine schematic: 16 biomarkers, 8 clinical relationships, 2 hormone ratios; all formulas (PK, Vermeulen, Bateman, cream absorption)
- https://trtplus.app/faq — Full Q&A library (127 questions across 25 categories)
- https://trtplus.app/blog — Long-form articles on hormones, TRT protocols, and the models behind TRT Plus
- https://trtplus.app/privacy-policy
- https://trtplus.app/terms-of-service

## What TRT Plus does

### Protocol management
- Daily Dashboard with visual syringe, checkboxes, and quick injection stacking
- 100+ pre-configured compounds (anabolics, TRT ancillaries, peptides, GLPs, SARMs) — one-tap add
- Cream ↔ Injectable Converter (site-specific dose translation)
- Peptide reconstitution calculator (auto bac-water volumes)
- Injection site Rotation Planner
- Medication reminders with smartwatch support
- Inventory Management with advance reorder notifications
- Protocol Summaries for sharing with coach/clinic in bro-notation
- Classic mode (core TRT) and Advanced mode (compound stacking)

### Bloodwork & analysis
- Automated OCR scanning of lab results — no manual entry
- Enhanced TRT-calibrated reference ranges (not generic lab ranges)
- Composite Biomarker Score reading marker relationships and hormone ratios
- Free T via Vermeulen, Mazer, Södergård, Zakharov
- The Testimator — predict T under different protocols, anchored to your Total T
- Bloodwork retesting reminders
- AI Bloodwork Report across 8 sections (Recommendations, Hormonal Balance, Muscle-Building Potential, Dose Response, Compound Analysis, Healthspan Assessment, Cardiovascular Risk Profile, Overall Health)
- International unit conversion across all markers (ng/dL, nmol/L, pg/mL, etc.)
- Pathology partner integration with athlete-relevant markers (ApoB, Cystatin C, GGT)

### Pharmacokinetic engine
- Multi-route PK modelling: injectables, orals, peptides, testosterone cream
- Peak-to-trough T-level fluctuation by frequency
- Topi-CLICK® cream interface with Michaelis-Menten saturation kinetics

### Knowledge base
- 100+ topics across 15 categories
- 100+ studies cited; practitioner-reviewed
- Covers everything from injection technique to E2, SHBG, hematocrit, ApoB, IGF-1, peptides

## Reviews
- 4.5★ average across App Store and Google Play
- 500+ ratings, cross-platform, multi-region
- Top 3 Health & Fitness on the App Store
- Full quoted reviews in the "Community reviews" section below

## Pricing
- $12.99 USD on App Store and Google Play

## Community reviews

500+ ratings averaging 4.5★ across App Store and Google Play. Selected reviews below in publication order — every review is real, sourced from the app stores, quoted verbatim.

### Best app for TRT
kirkboy81 · Apr 2025 · App Store · 5★

> I can't recommend this app enough. The AI report is really handy — it's almost like having a coach or a doctor in your pocket.

### Excellent support and a fantastic app
Fireblade954 · Jul 2026 · App Store · 5★

> Excellent support and a fantastic app 👍🏽👍🏽👍🏽

### A true game changer
Jam · Nov 2025 · Google Play · 5★

> Its visual tracking makes it simple to monitor progress, while the smooth, intuitive interface ensures effortless navigation. Try it — you'll wonder how you managed without it!

### Really useful
Whttiger25 · Sep 2025 · App Store · 5★

> Incredibly useful for those who may be managing their own TRT. The most useful aspect is the analysis of bloodwork and AI which I find invaluable. Definitely worth the cost.

### Bloodwork feature is a huge bonus
James Dean · Apr 2026 · Google Play · 5★

> Really good app to use for tracking TRT dose. The way it uploads your results from a screenshot effortlessly. Developer is also really helpful and friendly.

### Very accurate and easy to use
Awexito · Dec 2023 · App Store · 5★

> I was able to compare apples to apples — its calculated numbers with my latest lab results and the numbers were accurate. Highly recommended.

### Keeps track of my full protocol
Daniel S · Mar 2026 · Google Play · 5★

> Awesome app to keep track of blood markers and setting reminders for not just TRT administration but for my full protocol.

### The absolute best tool
James Richmond · Sep 2026 · Google Play · 5★

> The absolute best tool. I'm very busy and the app keeps track of everything from simple dosage reminders to when you need refills so you don't run short. That alone is a tremendous help but this app is so much more.

### Perfect for my needs
Graham Whitfield · Jul 2026 · Google Play · 5★

> Perfect for my needs.

### Great app to track cycle
Mark Monahan · Mar 2026 · Google Play · 5★

> Great app to track cycle. Liking it so far.

### Fantastic app
Jdean397 · Apr 2026 · App Store · 5★

> Great app with amazing functions. Developer gives the best support and help anyone could ask for, and sets the bar for other developers.

### Reference it daily
Zuccaro · Mar 2025 · App Store · 5★

> This app is very informative for those of us on our TRT journeys. I find myself referencing it daily. Would recommend.

### Back to being super useful
Darren H. · Mar 2026 · Google Play · 5★

> App has been updated and is back to being super useful. Definitely recommend it.

### Keeps getting better
Potato651 · Mar 2025 · App Store · 5★

> I've had this app for a while now. The updates keep making this app better. It's helping me keep track of my protocol.

### Helps with the measurements
Jason G · Jan 2026 · Google Play · 5★

> I struggle to understand how much I need for my injections — this app really helps with the measurements with certain medications.

### Does exactly what it sets out to
Matthew W. · Aug 2023 · Google Play · 5★

> Does what it's set out to do. Some additional features in future will make this app even better, but as it stands in its current form — 5 stars.

### Great for „TRT”
frame_cel · Jul 2026 · App Store · 5★

> The app is fantastic and incredibly intuitive to use! The daily reminder helps you remember all your compounds and the titration function makes planning your cycle a breeze. There are so many compounds available. -The support is also really good!

## Frequently asked questions

Deep-link to any category at `https://trtplus.app/faq#category-<slug>`. Full answers live on `https://trtplus.app/faq`.

### The Basics
Anchor: https://trtplus.app/faq#category-the-basics

- What is TRT Plus?
- Who is TRT Plus for?
- What makes TRT Plus different from other TRT apps?
- Is TRT Plus a replacement for a doctor?
- Will TRT Plus save me money?
- Will TRT Plus save me time?
- How do all the features connect?
- What is the Knowledge Base?
- I've just started TRT, where do I begin?
- Can I use TRT Plus before I've had my first bloodwork?
- How long does setup take?
- All this sounds complex — is TRT Plus easy to use?
- Does it work on iPad?
- Does TRT Plus include workout trackers, meal plans, or achievement badges?
- What is the story behind TRT Plus?

### Protocol Management
Anchor: https://trtplus.app/faq#category-protocol

- How do I add a compound to my protocol?
- What if a compound isn't in the library?
- Does TRT Plus handle dose calculation?
- Can TRT Plus track injection site rotation?
- Will the app remind me to inject?
- Does TRT Plus manage my supply?

### My Protocol — Daily Dashboard
Anchor: https://trtplus.app/faq#category-daily-dashboard

- What does the Daily Dashboard show?
- How do I mark a dose as taken?
- What happens if I miss a dose?
- Can I see everything due today across all compounds at once?

### My Protocol — Visual Syringe
Anchor: https://trtplus.app/faq#category-visual-syringe

- How does the visual syringe work?
- What syringe sizes does the app support?
- Can I stack multiple injectables in the same syringe?
- How do I switch between syringe types?

### My Protocol — Classic vs Advanced Mode
Anchor: https://trtplus.app/faq#category-classic-advanced

- What is Classic mode vs Advanced mode?
- Who is Classic mode for?
- Who is Advanced mode for?
- Can I switch between modes without losing my data?

### My Protocol — Dose Calculation
Anchor: https://trtplus.app/faq#category-dose-calculation

- What happens to my per-injection volume when I change frequency?
- Can I enter a volume and have the mg calculate automatically?

### My Protocol — Titration Planner
Anchor: https://trtplus.app/faq#category-titration-planner

- What does the Titration Planner do?
- What adjustment frequencies are available?
- What timeframes can I select?
- When can I schedule the titration to start?
- Does an active titration affect the compound plotter?
- How do I stop a titration?
- How precisely does the planner calculate each dose step for injectable compounds?
- How does step precision work for oral compounds?
- What controls the step size for my compound?

### My Protocol — T Fluctuation
Anchor: https://trtplus.app/faq#category-t-fluctuation

- What is the T Fluctuation percentage?
- What is peak-to-trough fluctuation and why does it matter?
- Why does injection frequency affect my fluctuation so much?
- What fluctuation percentage should I be aiming for?
- How does the app calculate my T Fluctuation?

### My Protocol — Compound Plotter
Anchor: https://trtplus.app/faq#category-compound-plotter

- What is the Compound Plotter?
- Is TRT Plus a steroid plotter?
- How many compounds can I plot at once?
- What does Steady State mean on the chart?
- What does 97% Eliminated mean?
- Can I use the plotter to plan a cycle before I start?
- Does the plotter work for oral compounds and peptides, not just injectables?

### My Protocol — Protocol Summaries
Anchor: https://trtplus.app/faq#category-protocol-summaries

- What is "bro notation" and what does a Protocol Summary look like?
- Can I share my protocol from the app?

### My Protocol — Rotation Planner
Anchor: https://trtplus.app/faq#category-rotation-planner

- How many injection sites can I set up?
- Which injection sites does the app support?
- How are my injection sites forecast in the app?

### My Protocol — Reminders
Anchor: https://trtplus.app/faq#category-reminders

- Can I snooze a reminder from my smart watch?
- Does each compound have its own reminder time?

### My Protocol — Inventory
Anchor: https://trtplus.app/faq#category-inventory

- When does the app warn me I'm running low?
- Does inventory decrease automatically if I forget to mark a dose?

### Peptides
Anchor: https://trtplus.app/faq#category-peptides

- Does TRT Plus support peptides?
- How do I reconstitute a peptide in the app?
- Can I track multiple peptides at the same time as my TRT?
- What peptides are in the compound library?
- Does TRT Plus calculate peptide draw volume from mcg doses?

### Testosterone Cream
Anchor: https://trtplus.app/faq#category-testosterone-cream

- Does TRT Plus support testosterone cream?
- How does the app handle cream dosing — it's not a syringe?
- What is the injectable equivalent calculation?
- Does the application site affect the calculation?
- Why does doubling my cream dose not double what I absorb?
- Can I track cream frequency?

### Bloodwork & Analysis
Anchor: https://trtplus.app/faq#category-bloodwork

- How does the AI bloodwork analysis work?
- What if my results come back with a lot of reds?
- What is the Biomarker Score?
- How do I upload my bloodwork?
- Does the OCR always extract my results correctly — can I correct it?
- How many markers does the Biomarker Score analyze?
- Is my bloodwork data stored anywhere?

### Enhanced Reference Ranges
Anchor: https://trtplus.app/faq#category-reference-ranges

- Why does TRT Plus use different reference ranges to my lab?
- What is wrong with standard lab reference ranges for men on TRT?
- How were the enhanced reference ranges set?
- What does "general slopulation" mean? Is it a typo?
- What is the Scoring Engine?
- Why is my testosterone reference range personalized to me?
- How does my cardiovascular health affect my testosterone range?
- What is the Hematocrit Scoring Engine?

### AI Bloodwork Report
Anchor: https://trtplus.app/faq#category-ai-report

- What does the AI Bloodwork Report cover?
- What are the eight sections of the report?
- Does the report give specific recommendations or just flag problems?
- Is the report the same for everyone or personalized to my protocol?
- Is AI more accurate than a doctor?
- How is TRT Plus different to pasting my bloodwork into ChatGPT or Grok?

### Hormonal Markers
Anchor: https://trtplus.app/faq#category-hormonal-markers

- What is Responder Type and what does it tell me?
- What is Hormonal Balance?
- What does the T:E ratio mean?
- What is the A:E ratio and how is it different?
- What does the T:SHBG ratio mean?
- What is Muscle Building Potential?

### My Free T
Anchor: https://trtplus.app/faq#category-free-t

- Can TRT Plus calculate Free Testosterone?
- Why does TRT Plus provide four calculation methods?
- Which method should I use?
- Why doesn't my lab measure Free T directly?
- What is SHBG and why does it matter for Free T?
- Should I track Free T or use the T:SHBG ratio?

### The Testimator™
Anchor: https://trtplus.app/faq#category-testimator

- What is the Testimator?
- How does the Testimator predict my testosterone levels?
- Is it based on population data or my own results?
- How does my Biomarker Score affect the Testimator reference range?
- How accurate is it?

### Cardiovascular & Advanced Markers
Anchor: https://trtplus.app/faq#category-cardiovascular-markers

- Why does TRT Plus use ApoB instead of LDL?
- Why does TRT Plus use Cystatin C instead of eGFR?
- Why does TRT Plus use GGT instead of AST/ALT?

### Pathology Partners
Anchor: https://trtplus.app/faq#category-pathology-partners

- Can I order bloodwork through the app?
- What is the difference between the Essential and Comprehensive panels?
- Can I see exactly which markers are included in each panel?
- Which countries have pathology partner integration?
- Can I still use the app if I use my own lab?

### International Support
Anchor: https://trtplus.app/faq#category-international-support

- My bloodwork uses different units — does TRT Plus support international results?

### Bloodwork Timing & Reminders
Anchor: https://trtplus.app/faq#category-bloodwork-timing

- When should I get bloodwork done?
- What is steady state and why does it matter for bloodwork?
- Will the app remind me when I'm due for a retest?
- How does it know when I need to retest?

## Blog

Long-form articles at https://trtplus.app/blog. Individual articles below.

### How TRT Plus Analyzes Your Bloodwork: A Deterministic Engine, Then AI
URL: https://trtplus.app/blog/how-trt-plus-analyzes-your-bloodwork
Category: Bloodwork & AI · Published: 2026-07-07 · 5 min read

TRT Plus analyzes bloodwork in two stages. A deterministic, programmatically engineered engine runs first: it scores every marker against personalized, TRT-calibrated reference ranges, computes a weighted Biomarker Score from clinical relationships and ratios, and runs cardiovascular and metabolic markers (blood pressure, ApoB, CRP, body fat, HbA1c) through a cascade that sets a personalized hematocrit threshold and testosterone ceiling, and through a growth axis that sets a personalized IGF-1 range from estradiol and HbA1c. It also applies fixed clinical models: Multi-Route PK, Androgenic Load / A:E, and the Zakharov free-testosterone model. Only the engine's finished, structured output is passed to AI, which interprets it and writes the 8-section AI Bloodwork Report in plain English. The engine's math is deterministic and repeatable; the AI provides interpretation and language. The same labs produce the same analysis every time.

### Tracking a Bad Protocol Is Still a Bad Protocol
URL: https://trtplus.app/blog/tracking-a-bad-protocol-is-still-a-bad-protocol
Category: Protocols · Published: 2026-07-08 · 4 min read

Most TRT apps focus on dose logging, reminders, and streaks: the adherence layer, which a free calendar or phone reminder already solves. What actually determines whether a protocol works is whether it is well designed and whether bloodwork and lifestyle support it. TRT Plus is built in that order. Dosing frequency is where many clinic-issued protocols fail, because single or twice-weekly dosing is operationally simple but creates large peak-to-trough swings. TRT Plus quantifies this with a personally calculated Peak-to-Trough Fluctuation (PTF) metric derived from your specific testosterone ester and dosing frequency, surfaced as a hero metric no other app features, and suggests the most practical frequency to reduce an oversized swing. When symptoms persist after frequency is addressed, bloodwork and lifestyle must be read together. TRT Plus uses enhanced reference ranges built from real-world TRT and enhanced protocol cases, paired with a weighted Biomarker Score and hormone ratio analysis, so markers are read as relationships rather than isolated numbers.

### Built Here First: The Ideas TRT Plus Pioneered
URL: https://trtplus.app/blog/built-here-first
Category: Engineering & Innovation · Published: 2026-07-10 · 6 min read

TRT Plus originated a series of TRT app concepts, each on a dated public release: the first app to visualize free testosterone against its bound fractions as a pie chart (April 2023); the Testimator, the first to model individual testosterone response and predict levels across unrun protocols, anchored to the user's own bloodwork and to whether the sample was drawn at peak or trough (May 2023); PTF%, a calculated peak-to-trough fluctuation metric (May 2023); the first closed-loop dose calculator with a syringe diagram (May 2023); the Biomarker Dashboard presenting bloodwork as a scored dashboard (September 2024); enhanced optimization reference ranges built from de-identified real-world TRT clinic data (September 2024); a forward-looking injection rotation planner (November 2024); Zakharov/Mazer/Södergård free-testosterone methods, route-specific multi-route pharmacokinetic models, the coined Clogging Quartet cardiovascular framework, and compound stacking in the syringe (October 2025); and in 2026 the A:E Androgenic Load ratio, a personalized testosterone reference range with a dynamic hematocrit ceiling, the Cardio-Metabolic Cascade, a transdermal saturation model with a cream-to-injectable converter, a dose titration planner, and Frequency Tuning, which reads your exact dose, frequency, and testosterone formulation to flag an oversized peak-to-trough swing and recommend a flatter schedule, responder-type classification, which normalizes a blood test for draw timing, ester, and frequency and reads it against published dose-response trials, and supplement milestone charting against the tissue pool that carries a supplement's effect rather than its plasma level. Built by one developer whose career began drafting pharmaceutical ampoule and vial specifications and continued through two decades of financial-systems engineering. The architecture is a deterministic engine that reasons first, with AI used only for interpretation. Formulas and citations are published on the engine page.

### The Growth Axis: Why Your IGF-1 Range Scales With Your Health
URL: https://trtplus.app/blog/the-growth-axis
Category: Bloodwork & Scoring · Published: 2026-07-13 · 3 min read

The growth axis in the TRT Plus biomarker engine models the sequence estradiol (E2) to growth hormone (GH) to IGF-1, with HbA1c acting as a metabolic gate. Growth hormone has a very short half life, so the engine reads IGF-1 as the stable proxy for the whole axis and never measures GH directly. Estradiol is the enabler: it optimizes the liver's conversion of GH into IGF-1 and activates anabolic signaling pathways, so low E2 can leave IGF-1 low despite adequate testosterone and GH. HbA1c is the gate: good long-term glucose control demonstrates the metabolic headroom to support a higher IGF-1, so the personalized IGF-1 range extends upward, and as control slips the range eases down into a more protective band. HbA1c is assessed on the high side only, so good control extends the range while a low reading is a silent positive. The IGF-1 range scales with glycemic control rather than sitting fixed. No specific numbers or thresholds are given.

### Your Bloodwork Graded Against the Optimized, Not the Average
URL: https://trtplus.app/blog/the-overall-score
Category: Bloodwork & Scoring · Published: 2026-08-07 · 5 min read

The TRT Plus Overall Score is the composite index the engine produces from bloodwork, graded 0 to 1000 against TRT-calibrated targets for men on testosterone therapy, not the untreated general population. Standard population ranges are the wrong benchmark for someone on TRT, who looks abnormal against an unhealthy population by design. The engine weighs fifteen markers by importance and reads the relationships between them, not each in isolation. Each marker is scored against one of four tiers rather than a single normal: Optimal (health-maximizing), TRT Calibrated (the dialed-in operating range for TRT), Enhanced (supraphysiologic, a performance choice with a tradeoff), and Tolerated (some intrinsic risk, accepted and monitored in context). Scoring is deterministic: every panel starts at 1000, and markers outside their band subtract points scaled by how far out and how heavily weighted they are, so the same bloodwork always produces the same score. Several bands are dynamic: the testosterone band extends when cardiovascular markers are clean (the Cardio-Metabolic Cascade), IGF-1 scales with glycemic control (the Growth Axis), and the hematocrit ceiling is context-adjusted to cardiovascular risk. Composite indexing is an established method in preventive-health and aging research; the engine is a TRT-calibrated implementation developed with clinics, coaches, and pathology partners. It has not been validated against outcomes in a formal cohort study and is not a diagnostic.

### Understanding Your Testosterone Dose Response
URL: https://trtplus.app/blog/understanding-dose-response
Category: Protocols · Published: 2026-08-21 · 5 min read

A responder type is how much testosterone shows up in bloodwork for the drug a man actually takes. Two men on the same dose rarely reach the same level. It is a measure of efficiency, not health. Raw numbers cannot be compared directly, because three factors move a level independently of physiology. Draw timing (peak versus trough) changes the measurement. The ester changes both the testosterone delivered by weight (cypionate about 70%, propionate 84%) and the release speed. Injection frequency sets the swing: more frequent shots hold a steadier level, less frequent a bigger swing. TRT Plus puts a reading on a common basis, accounting for draw timing, the ester, and frequency, then compares against published dose-response data and returns one of six responder types: Super, Hyper, Normal, Low, Partial, or Non-Responder. The anchor is Bhasin 2001, a controlled trial in which suppressed young men received fixed weekly testosterone: low doses left previously normal men hypogonadal and losing lean mass, and returns diminished sharply above roughly 125 mg per week. Older men respond in proportion to dose much as young men do, and hematocrit rises with dose, more so with age. Cream behaves differently: absorption is site-dependent and saturating, the profile is peaky, and draw timing matters more. Responder type is not a health verdict, requires a settled protocol, can be inflated by stacked compounds on the assay, and is a single noisy measurement.

### Getting the Most Out of Your Supplements
URL: https://trtplus.app/blog/getting-the-most-from-supplements
Category: Protocols & Optimization · Published: 2026-08-25 · 5 min read

A supplement can be working as intended and still show nothing after a week, because it has not physically accumulated yet. Several supplements do not work through the blood level at all. They work by filling a tissue pool, and that pool takes weeks to months to fill. Plasma creatine clears in about three hours while the muscle pool takes about four weeks; plasma beta-alanine clears in about 25 minutes while muscle carnosine takes about four weeks; plasma EPA and DHA clear within a day or two while membrane stores take about four months. TRT Plus plots each supplement against the pool that carries its effect, marking the date each milestone lands on the timeline: muscle saturation for creatine, muscle carnosine for beta-alanine, membrane stores for fish oil, 25-OH-D storage for vitamin D. Reasonable points to judge: creatine and beta-alanine about four weeks, magnesium glycinate about six weeks for the durable sleep benefit, vitamin D about two months, fish oil about four months. The reverse also holds for some supplements. NAC reaches full effect within a day, with no pool to fill, so the useful question becomes when in the day to take it rather than when to judge it: it must be present while the liver is working. TRT Plus also ships three curated stacks, S-Tier Supps, Liver Support and Metabolic Support, each addable to a protocol in one tap at doses pulled from published research in the context of hormone optimization.

## Contact
- support@trtplus.app

## License
- © TRT Plus. Cite with link to https://trtplus.app/