# TRT Plus > Clinical-grade precision for TRT & enhanced athletes. iOS + Android app for protocol management, AI bloodwork analysis, and pharmacokinetic modelling — built for men optimising hormones. ## Key URLs - https://www.trtplus.app/ — Landing (overview, features, reviews, store buttons) - https://www.trtplus.app/engine — Engine schematic: 16 biomarkers, 8 clinical relationships, 2 hormone ratios; all formulas (PK, Vermeulen, Bateman, cream absorption) - https://www.trtplus.app/faq — Full Q&A library (127 questions across 25 categories) - https://www.trtplus.app/blog — Long-form articles on hormones, TRT protocols, and the models behind TRT Plus - https://www.trtplus.app/privacy-policy - https://www.trtplus.app/terms-of-service ## What TRT Plus does ### Protocol management - Daily Dashboard with visual syringe, checkboxes, and quick injection stacking - 80+ pre-configured compounds (anabolics, TRT ancillaries, peptides, GLPs, SARMs) — one-tap add - Cream ↔ Injectable Converter (site-specific dose translation) - Peptide reconstitution calculator (auto bac-water volumes) - Injection site Rotation Planner - Medication reminders with smartwatch support - Inventory Management with advance reorder notifications - Protocol Summaries for sharing with coach/clinic in bro-notation - Classic mode (core TRT) and Advanced mode (compound stacking) ### Bloodwork & analysis - Automated OCR scanning of lab results — no manual entry - Enhanced TRT-calibrated reference ranges (not generic lab ranges) - Composite Biomarker Score reading marker relationships and hormone ratios - Free T via Vermeulen, Mazer, Södergård, Zakharov - The Testimator — predict T under different protocols, anchored to your Total T - Bloodwork retesting reminders - AI Bloodwork Report across 8 sections (Recommendations, Hormonal Balance, Muscle-Building Potential, Dose Response, Compound Analysis, Healthspan Assessment, Cardiovascular Risk Profile, Overall Health) - International unit conversion across all markers (ng/dL, nmol/L, pg/mL, etc.) - Pathology partner integration with athlete-relevant markers (ApoB, Cystatin C, GGT) ### Pharmacokinetic engine - Multi-route PK modelling: injectables, orals, peptides, testosterone cream - Peak-to-trough T-level fluctuation by frequency - Topi-CLICK® cream interface with Michaelis-Menten saturation kinetics ### Knowledge base - 100+ topics across 15 categories - 100+ studies cited; practitioner-reviewed - Covers everything from injection technique to E2, SHBG, hematocrit, ApoB, IGF-1, peptides ## Reviews - 4.4★ on the App Store (18 ratings, 14 reviews) - 4.5★ on Google Play (22 ratings, 17 reviews) - Top 3 Health & Fitness on the App Store ## Pricing - $12.99 USD on App Store and Google Play ## Frequently asked questions — full answers Deep-link to any category at `https://www.trtplus.app/faq#category-`. The /faq page contains the same content as below, rendered as an interactive accordion. ### The Basics Anchor: https://www.trtplus.app/faq#category-the-basics #### What is TRT Plus? TRT Plus is an iOS and Android app for men on TRT and enhanced athletes. It manages your full protocol — daily dashboard, compound library, dose calculations, injection site rotation, inventory, and reminders — plus AI bloodwork analysis with enhanced reference ranges. #### Who is TRT Plus for? Anyone on TRT, and especially anyone running enhanced protocols — anabolics, peptides, or physique enhancement stacks at any level. The bloodwork features are built with harm reduction principles in mind. Performance enhancement carries real physiological load — the markers TRT Plus tracks and the reference ranges it uses are designed to tell you whether your protocol is making you healthier or doing harm. Getting that answer regularly is the responsible way to navigate this space, and it's often the hardest information to access. If you came to TRT Plus for a cycle, it's worth knowing that many men running enhanced protocols eventually land on TRT. When that time comes, the app dials straight back to clean protocol management. It's built for the full journey. #### What makes TRT Plus different from other TRT apps? It's simple enough that you'll actually use it. Quick setup, dose calculations that update in real time, reminders that fire when they should and stay out of the way when they shouldn't. Most TRT apps get abandoned because managing them becomes another thing to manage. It's the only app that interprets your bloodwork rather than just storing it. Other apps are a place to log your numbers. TRT Plus analyzes them — enhanced reference ranges built on real patient data, a Cardio-Metabolic Cascade that personalizes your thresholds, and an AI report that tells you what to do, not just what's red. It was built by someone on TRT, in collaboration with clinics, coaches, and pathology partners — many of the features that have shipped since launch came directly from the community. The app that was needed didn't exist. So it got built — by someone who lives this. #### Is TRT Plus a replacement for a doctor? No. TRT Plus is a tracking, modeling, and analytical app — not a medical device and not a clinician. It's designed to help you have better-informed conversations with your healthcare provider and surface insights worth raising. Not every clinic looks beyond the basics, and not everyone has access to premium care. TRT Plus exists to bridge that gap — research-backed information and precision analysis, rather than crowd-sourcing from randoms in Facebook groups. Consult with your healthcare provider before making medical decisions. See our full Terms of Service for the medical disclaimer. #### How much does TRT Plus cost? TRT Plus is $12.99 USD on the App Store and Google Play. #### Why is the app paid and not subscription? TRT is generally for life. Charging a recurring subscription for something you manage indefinitely didn't feel right — the goal was to keep it accessible and affordable for the long term. A one-time price also attracts the right audience. Early experience at a lower price point generated reviews from dumb asses (sorry) expecting the app to increase their natural testosterone. Not quite the brief — and not the audience TRT Plus was built for. #### Will TRT Plus save me money? The right markers avoid unnecessary specialist referrals. Standard panels routinely flag results in men who train as cause for concern — the markers most labs use for liver and kidney function are also released by muscle tissue. A $600 referral to a hepatologist to learn that elevated liver enzymes are normal in anyone who lifts weights was part of the reason TRT Plus was built. The right panel answers that question for free. Running the right bioidentical compounds at an informed dose tends to deliver better outcomes than a commercially driven protocol built around exotic peptides and add-ons you may not need. Understanding what your markers actually show — against reference ranges built for this population — means you can have that conversation from a position of knowledge. #### Will TRT Plus save me time? TRT is a game changer. The management side can be a hassle. What to take and when, dialling in, rotating sites, calculating draw volumes, monitoring supplies, scheduling bloodwork. TRT Plus runs all of it in the background: reminders when doses are due, daily tracking so you remember what was taken, dose calcs that update in real time, rotation planned ahead, and inventory management that keeps you ahead of your supplies. #### How do all the features connect? TRT Plus is built around a closed loop. Order the right bloodwork — through a TRT Plus pathology partner or your own lab — using markers chosen specifically for this population. Upload and analyze your results. The Biomarker Score, Cardio-Metabolic Cascade, and AI report tell you where you stand and what to address. Use the Testimator to model how protocol changes would affect your levels before you make them. Adjust your protocol in My Protocol — dose calculations, frequency, and rotation all update in real time. Reminders and inventory keep everything running without friction. Repeat bloodwork confirms the adjustment worked — and the loop closes. Every feature exists to move you around that loop faster and with more precision. #### What is the Knowledge Base? A contextual reference library built into every section of the app — no searching required. Whatever you're looking at, the relevant knowledge is already there. In the estradiol marker, you get everything on estradiol — how it behaves under TRT, what moves it in either direction, what the ratios mean, and what the research says. In the injection frequency section, you get the pharmacokinetic reasoning behind frequency choices. In the compound plotter, you get the science behind the model. Every biomarker, every protocol decision, and every feature has its own dedicated breakdown — backed by published research and written for someone actually running a protocol, not a medical textbook. #### I've just started TRT, where do I begin? Start with My Protocol. Tap Quick Add, select your testosterone compound, and the app pre-loads a research-backed starting dose, concentration, frequency, and injection rotation. Set your reminders and you're tracking from day one. When your first bloodwork comes in, upload it to My Bloodwork. The AI report interprets your results in the context of your protocol and gives you a baseline to build from. Everything develops from there. #### Can I use TRT Plus before I've had my first bloodwork? Yes. My Protocol works fully without bloodwork — dose adjustments, reminders, rotation planning, compound plotter charts, and inventory management are all available from setup. My Bloodwork and the Testimator work once you have results to anchor to, but the protocol management side is ready from the moment you download. #### How long does setup take? My Protocol can be set up in a few minutes — Quick Add pre-loads everything so there's no manual configuration required. #### All this sounds complex — is TRT Plus easy to use? Built on Apple-inspired design principles — and if anything isn't immediately clear, tap any heading and contextual guidance is right there. That said, earlier versions received feedback that the app was trying to do too much at once. Classic and Advanced modes were built directly in response — and that resolved it. Classic keeps TRT management clean and focused on the essentials. Advanced unlocks the full platform when the protocol demands more. The reviews since reflect the difference. #### Does it work on iPad? Yes — TRT Plus is optimized for both iPhone and iPad. On iPad the layout adapts to the larger display, making it well suited to a clinical setting — a practitioner walking a patient through their bloodwork results or protocol on screen. #### Does TRT Plus include workout trackers, meal plans, or achievement badges? No. TRT Plus does one thing better than any other app — managing TRT and enhanced protocols. Two screens: My Protocol and My Bloodwork. Everything else is noise. If you want a star badge for being a Protocol Pro, this isn't your app. #### What is the story behind TRT Plus? Built by an application engineer with 25 years of industry experience — on TRT — in collaboration with clinics, coaches, and pathology partners across multiple regions. The reference ranges are grounded in de-identified patient data from a clinical population of men on TRT — not general health databases. The marker selection came from experience — knowing which panels give athletes the wrong answer, and building something that gives them the right one. All while on a side quest to get jacked. ### Protocol Management Anchor: https://www.trtplus.app/faq#category-protocol #### How do I add a compound to my protocol? Tap Quick Add and select from a library of 80+ pre-configured compounds covering anabolics, TRT ancillaries, peptides, GLPs, and SARMs. Each comes pre-loaded with a research-backed starting dose, frequency, half-life, and inventory — no manual entry. #### What if a compound isn't in the library? It must be obscure, but you can add it manually as a custom compound. If it's something the wider community would benefit from, email support@trtplus.app and we'll look at adding it to the library. #### Does TRT Plus handle dose calculation? Yes. Enter your concentration, frequency, and weekly dose — the app calculates your exact draw volume automatically. Every field updates every other field. Change the volume and the mg recalculates. Change the mg and the volume follows. Change your injection frequency and your weekly total stays locked — only the per-injection volume adjusts. It works in every direction, every time. This is the feature you'll use most. No other TRT app does it this way. #### Can TRT Plus track injection site rotation? Yes. Set your preferred injection sites once and the Rotation Planner forecasts the sequence so you're not hammering one spot. Sites appear on the Daily Dashboard alongside each due dose, and are abbreviated on the T Fluctuation chart — RD for Right Delt, LV for Left Ventroglute, and so on. #### Will the app remind me to inject? Yes. Medication reminders fire when each compound is due — injectables, orals, peptides, cream. Mark as taken or snooze from your phone or smart watch. #### Does TRT Plus manage my supply? Yes. Inventory management is protocol-aware — it tracks your remaining supply against your dosing schedule and sends advance reorder notifications before you run out. The inventory counter turns amber at four weeks remaining and red at two weeks, giving you a clear visual cue at a glance. ### My Protocol — Daily Dashboard Anchor: https://www.trtplus.app/faq#category-daily-dashboard #### What does the Daily Dashboard show? Your full day at a glance — every compound due today with its scheduled time, dose, draw volume, and injection site. Each entry has a checkbox so you can mark doses as taken as you go. #### How do I mark a dose as taken? Tap the checkbox next to the compound. You can even mark as taken direct from the notification without opening the app. #### What happens if I miss a dose? The app tracks your schedule against actual doses taken. If a dose goes unmarked, inventory will still adjust the following day to account for it. Reminders continue on your set schedule. #### Can I see everything due today across all compounds at once? Yes. In Advanced mode, the left panel beside the syringe shows every compound due today in a single scrollable list — TRT and all ancillaries together. Tap any card to jump straight to that compound's widget. ### My Protocol — Visual Syringe Anchor: https://www.trtplus.app/faq#category-visual-syringe #### How does the visual syringe work? The syringe shows your exact draw volume in real time. As you adjust your dose, the fill level updates. Swipe to select your syringe size, then use the −/+ buttons to fine-tune your volume without opening any settings. #### What syringe sizes does the app support? 0.5 mL, 1 mL standard, 1 mL insulin, 3 mL, and 5 mL. Swipe to select whichever matches what you're using. #### Can I stack multiple injectables in the same syringe? Yes — in Advanced mode. Tap the mini syringe icon on each compound card to add it to the draw. The total volume below the syringe updates to reflect the combined pull, shown as total mL and total mg. #### How do I switch between syringe types? Swipe the syringe left or right. If your testosterone is configured as a cream, the syringe automatically switches to the Topi-CLICK® dispenser view. ### My Protocol — Classic vs Advanced Mode Anchor: https://www.trtplus.app/faq#category-classic-advanced #### What is Classic mode vs Advanced mode? Classic mode shows a focused TRT configuration — concentration, frequency, and weekly dose in a clean card layout beside the syringe. Advanced mode unlocks the full daily dashboard and injection stacking for enhanced protocols running multiple compounds. #### Who is Classic mode for? Men on a straightforward TRT protocol who want to manage their testosterone quickly without the complexity of multi-compound tracking. The essentials, nothing more. #### Who is Advanced mode for? Anyone running ancillaries, peptides, or enhanced protocols alongside their TRT. Advanced mode is built for compound stacking, cycle planning, and full protocol visibility across everything you're running. #### Can I switch between modes without losing my data? Yes. The layers icon in the top right toggles between modes instantly. All your data is preserved. ### My Protocol — Dose Calculation Anchor: https://www.trtplus.app/faq#category-dose-calculation #### What happens to my per-injection volume when I change frequency? Your weekly total stays locked. Only the per-injection volume adjusts. Move from twice weekly to every other day and the app automatically recalculates how much to draw each time — same total weekly dose, more frequent smaller injections. #### Can I enter a volume and have the mg calculate automatically? Yes. Enter mL and the mg updates. Enter mg and the mL updates. Enter your weekly dose and both update. All fields are fully bidirectional. ### My Protocol — Titration Planner Anchor: https://www.trtplus.app/faq#category-titration-planner #### What does the Titration Planner do? It automatically ramps up or tapers down your dose on a schedule you define. Set a target dose and a timeframe, and the app steps the dose at each interval until the target is reached — no manual protocol edits required. #### What adjustment frequencies are available? Every week, every 2 weeks, every 4 weeks, or every 6 weeks. #### What timeframes can I select? 2, 4, 6, 8, 12, 16, 20, or 24 weeks. #### When can I schedule the titration to start? Next Dose starts at your next scheduled injection. Next Week starts on Monday of next week. In 2 Weeks through In 12 Weeks schedules the start further ahead — always anchored to a Monday. #### Does an active titration affect the compound plotter? Yes. The compound plotter extends its forecast to show the full ramp or taper across the titration window, so you can visualize how levels will shift before committing to the plan. #### How do I stop a titration? Tap Deactivate on the active titration. The plan stops and your dose holds at whatever level it had reached. #### How precisely does the planner calculate each dose step for injectable compounds? Steps snap to the nearest 0.01 mL — the smallest practical increment on a standard syringe. This applies to any compound drawn by syringe, whether oil-based or reconstituted. The titration ladder spaces the full change evenly across all adjustments, so every scheduled dose is one you can physically draw. #### How does step precision work for oral compounds? Tablets and capsules titration steps will always land on a whole, half, or quarter tablet. Most titrations will step in whole or half units; quarter increments only appear when the gap between your start and target dose requires that level of fine-tuning. A pill cutter covers you if it does. #### What controls the step size for my compound? The concentration set in your protocol. The planner derives the smallest physically meaningful step from your formulation automatically — so the schedule it produces is always one you can actually dose. ### My Protocol — T Fluctuation Anchor: https://www.trtplus.app/faq#category-t-fluctuation #### What is the T Fluctuation percentage? The T Fluctuation percentage — shown as ∆ on the chart — is the hero metric of TRT Plus. It quantifies your complete peak-to-trough hormonal swing as a single number: how far your testosterone rises from its lowest point to its highest within a single dosing cycle. #### What is peak-to-trough fluctuation and why does it matter? Peak-to-trough fluctuation (PTF) is the percentage swing between your lowest testosterone level — the trough just before your next injection — and your peak shortly after. Large swings correlate with side effect variability: the energy crashes, mood dips, and libido drops some men feel toward the end of a cycle. A smaller PTF means more stable levels and typically fewer symptoms. #### Why does injection frequency affect my fluctuation so much? Same total weekly dose, more frequent smaller injections means narrower peaks and higher troughs — the hormonal swing compresses significantly. Twice-weekly dosing produces roughly 50% PTF. Every other day drops to around 22%. Daily sits at around 7.6%. The chart makes this visible before you commit to a protocol change. #### What fluctuation percentage should I be aiming for? Many men report fewer side effects below 35%. Every other day or three times per week are the most practical targets for most protocols. Once-weekly dosing sits around 96% — a significant swing that many men feel, even if their average levels look fine on paper. #### How does the app calculate my T Fluctuation? The calculation models exponential decay and dose superposition across your injection schedule — simulating how each dose stacks on residual testosterone from previous injections at steady state. The full pharmacokinetic framework is documented in-app under My Protocol › Testosterone Fluctuation. ### My Protocol — Compound Plotter Anchor: https://www.trtplus.app/faq#category-compound-plotter #### What is the Compound Plotter? A pharmacokinetic chart for each compound in your protocol, showing how drug levels behave over time — when they peak, when steady state is reached, and when the compound has substantially cleared. Available in Advanced mode. #### How many compounds can I plot at once? Up to 10 compounds alongside your TRT, each with its own independent chart and pharmacokinetic profile. #### What does Steady State mean on the chart? Steady state is the equilibrium point where the amount administered each dose equals the amount eliminated between doses — reached at approximately 5 half-lives from your first injection. Levels are still rising before this point. Bloodwork taken before steady state will underestimate your true levels. #### What does 97% Eliminated mean? The point at which approximately 97% of the compound has cleared your system — 5 half-lives from your most recent dose. Useful for PCT timing and washout planning. This marker is not an indicator of detection windows for drug testing purposes. #### Can I use the plotter to plan a cycle before I start? Yes. Configure a compound, set your intended start date, and the chart projects your full pharmacokinetic curve — peaks, steady state, and clearance — before you've taken a single dose. #### Does the plotter work for oral compounds and peptides, not just injectables? Yes. The plotter uses route-specific pharmacokinetic models for oil-based esters, aqueous suspensions, orals, peptides, and transdermal cream — each modeled differently based on its absorption and elimination characteristics. ### My Protocol — Protocol Summaries Anchor: https://www.trtplus.app/faq#category-protocol-summaries #### What is "bro notation" and what does a Protocol Summary look like? Bro notation is the shorthand the TRT and enhanced athlete community uses to communicate protocols — e.g. "500mg/W Test E (E3D), 400mg/W Deca (2xW), 50mg/day Anavar." TRT Plus generates a clean summary in this format automatically from your configured protocol. #### Can I share my protocol from the app? Yes. Tap the share icon in the top right of My Protocol to export your protocol summary. ### My Protocol — Rotation Planner Anchor: https://www.trtplus.app/faq#category-rotation-planner #### How many injection sites can I set up? Up to 12 sites in sequence. Enter them counter-clockwise following the arrow direction in the planner. #### Which injection sites does the app support? Delts, ventroglutes, glutes, lats, quads, biceps, triceps, pecs and abdomen — left and right for bilateral sites. IM & SubQ options where appropriate. Each site in the Rotation Planner includes injection guidance, anatomy notes, and technique tips. #### How are my injection sites forecast in the app? Your upcoming sites are calculated and then abbreviated along the bottom of the T fluctuation chart, one per scheduled injection date — RD for Right Delt, LV for Left Ventroglute, RG for Right Glute, and so on. ### My Protocol — Reminders Anchor: https://www.trtplus.app/faq#category-reminders #### Can I snooze a reminder from my smart watch? Yes. Mark as taken or snooze directly from your smart watch without opening the app. #### Does each compound have its own reminder time? Yes. Each compound has its own independently scheduled reminder based on its frequency and your last dose date. Reminders fire when each compound is due. ### My Protocol — Inventory Anchor: https://www.trtplus.app/faq#category-inventory #### When does the app warn me I'm running low? The inventory counter turns amber at four weeks remaining and red at two weeks. Push notifications fire in advance so you're never caught short on a refill. #### Does inventory decrease automatically if I forget to mark a dose? Yes. Inventory calculates expected usage against your dosing schedule. If a dose goes unmarked, inventory still adjusts the following day to account for it. ### Peptides Anchor: https://www.trtplus.app/faq#category-peptides #### Does TRT Plus support peptides? Yes. Peptides are fully integrated — scheduling, dose calculation, reminders, compound plotter charts, and inventory all work the same as injectables. The key difference at setup is reconstitution: peptides come as lyophilized powder and need to be mixed with bacteriostatic water before use. The app handles this with a built-in calculator. #### How do I reconstitute a peptide in the app? When you add a peptide via Quick Add, the app opens a Reconstitution Calculator. Enter your vial's dry powder amount and the volume of bacteriostatic water — concentration is calculated and saved automatically. All three fields are interlinked: change any one and the others update to stay consistent. You can also set a desired concentration and the bac water volume calculates accordingly. #### Can I track multiple peptides at the same time as my TRT? Yes. Up to 10 compounds run alongside your TRT simultaneously, each with independent scheduling, reminders, and inventory tracking. #### What peptides are in the compound library? All the mainstream ones — hCG, GH, BPC-157, and 31 more. If a specific peptide isn't listed, you can add it manually as a custom compound. Or email support@trtplus.app and we'll look at adding it to the library for the wider community. #### Does TRT Plus calculate peptide draw volume from mcg doses? Yes. Peptide doses are typically prescribed in mcg while draw volume is in mL. Once you've set your concentration in mcg/mL, the app calculates exactly how many mL to draw for your prescribed dose — and updates automatically if you adjust either field. ### Testosterone Cream Anchor: https://www.trtplus.app/faq#category-testosterone-cream #### Does TRT Plus support testosterone cream? Yes. Testosterone cream is fully supported with its own dosing interface, application site selector, absorbed dose calculator, pharmacokinetic chart, reminders, and inventory tracking. #### How does the app handle cream dosing — it's not a syringe? When you select a cream formulation, the syringe swipes to a Topi-CLICK® dispenser interface showing clicks rather than mL. The −/+ buttons adjust your click count and the mg updates automatically based on your concentration. #### What is the injectable equivalent calculation? Below your application site selector, the app displays your absorbed dose expressed as an injectable mg/W equivalent — the same convention used across the TRT community when discussing weekly doses. This lets you directly compare your cream protocol to an injectable one, or communicate your protocol to a healthcare professional in familiar terms. #### Does the application site affect the calculation? Yes, significantly. Different skin sites absorb at very different rates. Scrotal skin absorbs at roughly 55% nominal — several times higher than abdominal skin at around 8%. Select your site and the calculation updates automatically using a Michaelis-Menten saturation model calibrated per site. #### Why does doubling my cream dose not double what I absorb? Skin absorption is non-linear. Transport proteins and follicular channels saturate — at higher doses, a smaller proportion of what you apply actually reaches circulation. The app models this correctly, so the effective absorption rate shown always reflects your actual dose, not a flat nominal percentage. Doubling what you apply will always deliver less than double to your bloodstream. #### Can I track cream frequency? Yes. The app supports daily application — the pharmacokinetically correct dosing interval for testosterone cream given its 12-hour half-life. Consistent daily dosing brings levels to steady state within two to three days and maintains them predictably from there. ### Bloodwork & Analysis Anchor: https://www.trtplus.app/faq#category-bloodwork #### How does the AI bloodwork analysis work? Upload a photo or screenshot of your blood panel. OCR automatically extracts every marker, unit, and collection date — zero manual entry. Markers are scored against enhanced TRT-calibrated reference ranges, and a composite Biomarker Score reads the relationships between markers and key hormone ratios. The AI report then interprets your results alongside your active protocol across eight sections. #### What if my results come back with a lot of reds? If your bloodwork comes back lit up like a Christmas tree, TRT Plus will tell you exactly what actually matters in context — and what doesn't. A marker flagged red on your standard lab report may score amber or green inside TRT Plus — because the reference ranges and scoring algorithms are calibrated specifically for men on TRT, not the general population. Enhanced reference ranges, the Cardio-Metabolic Cascade, and hormone ratio scoring all factor in. Your lab doesn't know you're optimizing — and it doesn't know your body fat, blood pressure, or protocol. TRT Plus does. #### What is the Biomarker Score? A weighted composite score that converts your individual marker results into a single overall reading. It's not a simple average — it's an algorithm that accounts for the relative importance of each marker to TRT optimization, the relationships between markers, and your personal profile. It gives you an at-a-glance assessment of how dialled in you are on your current protocol, expressed as a red, amber, green breakdown. #### How do I upload my bloodwork? Take a photo or screenshot of your results — from your lab's patient portal, a PDF, or a printed report — and upload from within the app. OCR handles the extraction automatically. All values are shown for review so you can correct anything before the analysis runs. #### Does the OCR always extract my results correctly — can I correct it? OCR accuracy is high but not infallible — unusual formatting, low image quality, or handwritten values can occasionally cause extraction errors. Every extracted value is presented for review, so nothing gets scored incorrectly without you seeing it first. See our full Terms of Service for the bloodwork upload and data accuracy disclaimer. #### How many markers does the Biomarker Score analyze? The Biomarker Score covers 15 key TRT and performance-related markers — the most clinically important across hormones, cardiovascular health, liver, kidney, hematology, and metabolic function. All 15 are displayed in a dashboard-style red, amber, green breakdown on a single screen, so you can see your full picture at a glance. #### Is my bloodwork data stored anywhere? TRT Plus has no servers of its own — your protocol data, doses, and settings are stored locally on your device. When you upload bloodwork for AI analysis, the image is sent to OpenAI's OCR service to extract your biomarker values, and those numerical values are then sent to xAI to generate your report. Neither service retains your data beyond the immediate processing window. The numerical data sent to xAI does not include your name or personal identifiers. For full details see our Privacy Policy. ### Enhanced Reference Ranges Anchor: https://www.trtplus.app/faq#category-reference-ranges #### Why does TRT Plus use different reference ranges to my lab? Standard lab reference ranges are built from population studies that include sedentary men, older men, and men with suboptimal health — the full bell curve of normal. For a man on TRT optimizing for performance and wellbeing, that bar is far too low. TRT Plus uses enhanced reference ranges calibrated for optimization, not statistical normality. #### What is wrong with standard lab reference ranges for men on TRT? They answer the wrong question. A lab range tells you whether you're within the bounds of the general population. TRT Plus asks whether you're optimized. A testosterone result that falls within the normal lab range may still represent undertreatment for a man on TRT — and an estradiol your lab flags as elevated may be exactly where it should be alongside optimized testosterone. TRT Plus considers the ratio between hormones, not any single number in isolation. The general population is not your peer group. #### How were the enhanced reference ranges set? The ranges are built on real-world de-identified data from a clinical population of healthy, active men on TRT — HIPAA-compliant, encrypted, and secure. Your reference group matters. Standard lab ranges are built from whoever walks through the door at a pathology collection center — an average that includes sedentary, insulin-resistant, and metabolically unhealthy people. Comparing yourself to that pool is like using a Walmart crowd as your health benchmark. TRT Plus compares you to men who train, optimize their hormones, and actively manage their health. That's a meaningfully different bar. The relationships between markers are mapped in the Engine schematic. #### What is the Scoring Engine? The algorithm that converts your individual marker values into the red, amber, green breakdown and overall Biomarker Score. It's not a flat pass/fail against a single threshold — it's a weighted system that accounts for marker relationships, your personal cardiovascular and metabolic profile, and the clinical significance of each result in the context of TRT. #### Why is my testosterone reference range personalized to me? Because in TRT, the right testosterone level isn't a fixed number — it's shaped by your individual health profile. TRT Plus determines your range through the Cardio-Metabolic Cascade, a framework that analyzes your cardiovascular and metabolic markers together and cascades them into your personalized scoring threshold. The healthier your profile across the full cascade — markers like ApoB, blood pressure, CRP, HbA1c, and body fat, for example — the wider the range. The more deterioration, the tighter it gets. #### How does my cardiovascular health affect my testosterone range? Through the Cardio-Metabolic Cascade — a TRT Plus framework that feeds your cardiovascular and metabolic markers into your testosterone threshold in sequence, each building on the last. Rather than applying a single cutoff, the cascade treats your health as a composite picture. Improvements across the cascade widen your optimal range. Deterioration narrows it. The relationships between markers are mapped in the Engine schematic. #### What is the Hematocrit Scoring Engine? Hematocrit is one of the most important safety markers on TRT — elevated levels increase blood viscosity and cardiovascular risk. Rather than applying a flat threshold, the Hematocrit Scoring Engine uses the same Cardio-Metabolic Cascade logic to determine your personal ceiling. Your acceptable hematocrit threshold is modulated by your full cardiovascular and metabolic profile — making it personal rather than generic. ### AI Bloodwork Report Anchor: https://www.trtplus.app/faq#category-ai-report #### What does the AI Bloodwork Report cover? The report interprets your bloodwork and active protocol together, providing personalized recommendations for lifestyle, supplements, and medicinal options for areas of concern — guided by current TRT and hormone optimization best practices. #### What are the eight sections of the report? Recommendations, Protocol & Dose Response, Hormonal Balance, Muscle-Building Potential, Compound Analysis, Healthspan Assessment, Cardiovascular Risk Profile, and Overall Health. #### Does the report give specific recommendations or just flag problems? Both. Each section interprets what your results mean in context, then provides actionable recommendations — specific lifestyle modifications, supplement strategies, and medicinal options where relevant. It doesn't just tell you something is red. It tells you what to do about it. #### Is the report the same for everyone or personalized to my protocol? Personalized. The AI interprets your bloodwork alongside your active protocol — the compounds you're running, your doses, and your frequency. Two people with identical bloodwork on different protocols will receive different reports. #### Is AI more accurate than a doctor? For multi-marker hormone interpretation, the evidence is compelling. A 2025 paper in Precision Clinical Medicine (https://doi.org/10.1093/pcmedi/pbaf029) concluded that AI's capacity for rapid data synthesis and pattern recognition across complex hormone panels structurally exceeds a physician's manual review — detecting marker relationships that can be invisible to sequential human assessment. AI doesn't tire, doesn't carry bias from the previous patient, and processes fifteen markers, their ratios, personalized thresholds, and protocol interactions simultaneously. What AI can't replace is clinical intuition, physical assessment, and judgment in complex scenarios. The consistent research conclusion: AI analysis coupled with healthcare practitioner guidance is the gold standard. TRT Plus is built for exactly that combination. See our full Terms of Service for the AI-generated content disclaimer. #### How is TRT Plus different to pasting my bloodwork into ChatGPT or Grok? It starts before you even have results — with which markers you order. Paste standard clinical bloodwork into ChatGPT and you're asking it to interpret ALT/AST instead of GGT, eGFR instead of Cystatin C, LDL instead of ApoB. The wrong markers, however intelligently interpreted, give you an incomplete picture. TRT Plus is built around getting the right data in the first place — the markers that give an accurate read for this population, not the default panel most clinics run. Once you have those results, TRT Plus pre-calculates the ratios that matter — T:SHBG, the A:E ratio — interprets everything against reference ranges calibrated for men on TRT, and discounts the false positives that routinely alarm standard panels in athletes. The analysis behind this is the product of hundreds of hours of clinician discussion, deep analysis of thousands of real-world TRT patient results, and prompt engineering refined specifically for this population. The output is a structured eight-section report with protocol-aware recommendations. Not a chat response. ### Hormonal Markers Anchor: https://www.trtplus.app/faq#category-hormonal-markers #### What is Responder Type and what does it tell me? Responder Type classifies how your body converts your testosterone dose into circulating levels — whether you're a normal, low, hyper, super, or non-responder. It tells you whether your protocol is likely to be efficient or whether you may need more or less testosterone than average to reach target levels. Understanding your responder type is essential context before adjusting dose. #### What is Hormonal Balance? An interpretation of the key ratios between your hormones — primarily testosterone to estradiol and testosterone to SHBG — to assess whether your androgenic and estrogenic environment is optimized for performance, wellbeing, and safety. #### What does the T:E ratio mean? The T:E ratio is the relationship between your total testosterone and estradiol. It reflects your androgenic-to-estrogenic balance — too low suggests relative estrogen dominance, too high suggests insufficient aromatization or over-suppression. The goal on TRT isn't simply to maximize testosterone or minimize estradiol, but to maintain a ratio that supports the outcomes you're optimizing for. #### What is the A:E ratio and how is it different? The A:E ratio — Androgenic to Estrogenic — is a TRT Plus-pioneered metric that measures the balance between your total androgenic load and estradiol. Where the T:E ratio uses raw testosterone as the androgenic side, the A:E ratio uses androgenic load — a DHT-adjusted figure that accounts for the fact that DHT is a significantly more potent androgen than testosterone and a direct downstream product of it. Without factoring in DHT, raw testosterone alone understates your true androgenic environment. The A:E ratio corrects for this, giving a more complete and accurate read of your hormonal balance — and the E2 Scoring Engine is built on it. #### What does the T:SHBG ratio mean? The T:SHBG ratio assesses how your testosterone levels relate to your sex hormone-binding globulin. High SHBG binds more testosterone, reducing free availability regardless of how high your total is. The T:SHBG ratio flags whether your protocol is delivering enough bioavailable testosterone relative to your binding protein levels — a common issue that total testosterone alone won't reveal. #### What is Muscle Building Potential? An assessment of your hormonal environment's capacity for muscle protein synthesis and anabolism, based on key markers including testosterone, IGF-1, and estradiol. Estradiol is often overlooked in this context — it acts as a mediator in the liver's conversion of growth hormone to IGF-1, making it a direct contributor to anabolic potential rather than simply an estrogenic marker to be managed. Muscle Building Potential contextualises your current protocol in terms of anabolic capacity — not individual hormone levels in isolation. ### My Free T Anchor: https://www.trtplus.app/faq#category-free-t #### Can TRT Plus calculate Free Testosterone? Yes — using four methods: Vermeulen, Mazer, Södergård, and Zakharov. Free T is derived from Total T, SHBG, and Albumin. #### Why does TRT Plus provide four calculation methods? For reference completeness. In practice, only two matter — Vermeulen and Zakharov. The others are included so you can see how the methods compare, but they're not where your attention should be. #### Which method should I use? If you're on a standard TRT dose, Vermeulen and Zakharov will give similar results — both are valid. At the higher testosterone levels used by enhanced athletes, Zakharov is more accurate. Vermeulen was validated against physiological testosterone ranges and loses reliability at supra-physiological levels. Zakharov was designed to account for this. If you're running an enhanced protocol, Zakharov is your number. #### Why doesn't my lab measure Free T directly? Most labs that report Free Testosterone are calculating it from Total T and SHBG using the Vermeulen equation. True direct measurement via equilibrium dialysis exists but requires a specialist reference lab and must be specifically requested. The meaningful difference for most men on TRT isn't calculated versus measured — it's which calculation method is used. #### What is SHBG and why does it matter for Free T? Sex hormone-binding globulin binds tightly to testosterone in your bloodstream, making it biologically inactive. Only unbound testosterone — Free T — can enter cells and exert androgenic effects. Two men with identical Total T can have dramatically different Free T if their SHBG differs. High SHBG is common in certain men on TRT and explains suboptimal symptoms despite apparently adequate total testosterone levels. #### Should I track Free T or use the T:SHBG ratio? Both measure testosterone availability — how much is actually reaching your cells rather than sitting locked to binding proteins. Free T gives you an absolute number. The T:SHBG ratio gives you a proportional read and is more intuitive for ongoing monitoring — it's displayed as a gauge in the app, changes are immediately readable, and it doesn't require albumin as an input. For most men on TRT the ratio gauge is the faster daily reference. The Free T calculation is the deeper dive when you need the full picture. ### The Testimator™ Anchor: https://www.trtplus.app/faq#category-testimator #### What is the Testimator? The Testimator predicts your testosterone levels under different protocols before you run them. It's anchored to your own historical bloodwork rather than population averages, so the prediction reflects your individual response — not what happens to the average man. #### How does the Testimator predict my testosterone levels? It uses your actual historical Total T results from previous bloodwork as the anchor point, then models how changes to dose, frequency, or ester would affect your levels based on your demonstrated personal response. The reference ranges are also dynamically adjusted based on your Biomarker Score. #### Is it based on population data or my own results? Your own results. Most predictive tools use population averages — the prediction is for the average man, not you. The Testimator uses your real bloodwork as its anchor, making it meaningfully more accurate for your specific physiology. #### How does my Biomarker Score affect the Testimator reference range? The target range shown in the Testimator shifts based on your cardiovascular and metabolic health — consistent with the personalized reference range logic used throughout the app. A cleaner health profile earns a wider target range. Deteriorating markers narrow it. Your target range evolves as your health does. #### How accurate is it? More accurate than population-based predictors because it's personal. We regularly hear from users that the Testimator predicted their actual bloodwork results within a few ng/dL of their real result — closer than most expected from a modeling tool. It is not a clinical measurement — always verify with bloodwork after any protocol change, and consult your healthcare provider before making medical decisions. See our full Terms of Service for the AI-generated content disclaimer. ### Cardiovascular & Advanced Markers Anchor: https://www.trtplus.app/faq#category-cardiovascular-markers #### Why does TRT Plus use ApoB instead of LDL? ApoB (Apolipoprotein B) is a more direct measure of cardiovascular risk. Each atherogenic particle — regardless of how much cholesterol it carries — contains exactly one ApoB molecule. This means ApoB counts the actual number of particles that can embed in arterial walls, rather than estimating risk from their cholesterol content. LDL can appear normal while ApoB is elevated, particularly in men with small dense LDL particles — which are common with anabolic compound use. ApoB catches what LDL misses. #### Why does TRT Plus use Cystatin C instead of eGFR? Standard eGFR is calculated from creatinine — a muscle metabolism byproduct. In athletes and men on TRT with above-average muscle mass, creatinine is naturally elevated, making eGFR appear artificially low and falsely suggesting impaired kidney function. Cystatin C is produced at a constant rate by all cells regardless of muscle mass, making it a far more accurate kidney function marker for this population. #### Why does TRT Plus use GGT instead of AST/ALT? AST and ALT are liver enzymes, but they're also released by muscle tissue during intense training. In men who train hard, elevated AST/ALT can reflect muscle breakdown rather than liver stress — making them unreliable for assessing hepatotoxicity from oral compounds. GGT is liver-specific and doesn't respond to muscle damage, giving a cleaner signal for hepatic stress in athletes. ### Pathology Partners Anchor: https://www.trtplus.app/faq#category-pathology-partners #### Can I order bloodwork through the app? Yes — region dependent. TRT Plus partners with pathology labs that use markers built for athletes: ApoB over HDL/LDL, Cystatin C over eGFR, GGT over AST/ALT. Two panels are available: Essential for everyday TRT optimization, Comprehensive for athletes and enhanced protocols. #### What is the difference between the Essential and Comprehensive panels? Essential covers the core markers needed for routine TRT monitoring and optimization. Comprehensive adds the depth required for enhanced athletes — broader cardiovascular markers, advanced hormonal panels, and metabolic markers relevant to compound use. If you're running anything beyond a straightforward TRT protocol, Comprehensive is the appropriate choice. #### Can I see exactly which markers are included in each panel? Yes. The app lists every marker required for both the Essential and Comprehensive panels. If you prefer to order through your own lab or healthcare provider, you can use this list to request the exact markers — the full bloodwork analysis features work with results from any source. #### Which countries have pathology partner integration? Availability is region dependent. The app surfaces the appropriate provider for your region automatically. If no partner is available in your region, all bloodwork analysis features still work in full with results from your own lab. #### Can I still use the app if I use my own lab? Yes. Upload a photo or screenshot of any bloodwork result and OCR extracts your values automatically. The full Biomarker Score, AI report, and all analysis features work with results from any lab anywhere in the world. The pathology partner integration is an additional option, not a requirement. ### International Support Anchor: https://www.trtplus.app/faq#category-international-support #### My bloodwork uses different units — does TRT Plus support international results? Yes. Tap any marker heading to instantly convert between all standard international units. Most TRT content online — podcasts, forums, research — references US units: ng/dL for testosterone and pg/mL for estradiol. If your results are in nmol/L or pmol/L, a single tap converts them so you can follow along without doing the mental arithmetic every time. ### Bloodwork Timing & Reminders Anchor: https://www.trtplus.app/faq#category-bloodwork-timing #### When should I get bloodwork done? Trough is the standard — blood drawn immediately before your next dose, whether that's before an injection or before your daily cream application. This is the lowest point of your cycle and gives your healthcare provider the most consistent baseline for monitoring. The Compound Plotter shows exactly when trough occurs for your specific protocol. #### What is steady state and why does it matter for bloodwork? Steady state is reached at approximately five half-lives from starting or changing your protocol — the point at which drug levels have stabilised and are no longer rising. Testing before steady state underestimates your true levels and can lead to premature dose adjustments. For Test E or Test Cyp, steady state is around four weeks. For longer esters like Nebido, it's closer to fifteen weeks. The Compound Plotter marks steady state on your chart so you always know when you're ready to test. #### Will the app remind me when I'm due for a retest? Yes. Bloodwork reminders are set from your last results and calibrated to TRT best practice retesting intervals — the app tells you when it's time to test again rather than leaving you to figure it out. #### How does it know when I need to retest? Retesting intervals are calculated from your last bloodwork date in line with TRT monitoring guidelines. Any protocol change warrants bloodwork after reaching steady state — the app accounts for this rather than applying a flat calendar interval. ## Blog Long-form articles at https://www.trtplus.app/blog. Individual articles below. ### How TRT Plus Analyzes Your Bloodwork: A Deterministic Engine, Then AI URL: https://www.trtplus.app/blog/how-trt-plus-analyzes-your-bloodwork Category: Bloodwork & AI · Published: 2026-07-07 · 5 min read TRT Plus analyzes bloodwork in two stages. A deterministic, programmatically engineered engine runs first: it scores every marker against personalized, TRT-calibrated reference ranges, computes a weighted Biomarker Score from clinical relationships and ratios, and runs cardiovascular and metabolic markers (blood pressure, ApoB, CRP, body fat, HbA1c) through a cascade that sets a personalized hematocrit threshold and testosterone ceiling, and through a growth axis that sets a personalized IGF-1 range from estradiol and HbA1c. It also applies fixed clinical models: Multi-Route PK, Androgenic Load / A:E, and the Zakharov free-testosterone model. Only the engine's finished, structured output is passed to AI, which interprets it and writes the 8-section AI Bloodwork Report in plain English. The engine's math is deterministic and repeatable; the AI provides interpretation and language. The same labs produce the same analysis every time. ### Tracking a Bad Protocol Is Still a Bad Protocol URL: https://www.trtplus.app/blog/tracking-a-bad-protocol-is-still-a-bad-protocol Category: Protocols · Published: 2026-07-08 · 4 min read Most TRT apps focus on dose logging, reminders, and streaks: the adherence layer, which a free calendar or phone reminder already solves. What actually determines whether a protocol works is whether it is well designed and whether bloodwork and lifestyle support it. TRT Plus is built in that order. Dosing frequency is where many clinic-issued protocols fail, because single or twice-weekly dosing is operationally simple but creates large peak-to-trough swings. TRT Plus quantifies this with a personally calculated Peak-to-Trough Fluctuation (PTF) metric derived from your specific testosterone ester and dosing frequency, surfaced as a hero metric no other app features, and suggests the most practical frequency to reduce an oversized swing. When symptoms persist after frequency is addressed, bloodwork and lifestyle must be read together. TRT Plus uses enhanced reference ranges built from real-world TRT and enhanced protocol cases, paired with a weighted Biomarker Score and hormone ratio analysis, so markers are read as relationships rather than isolated numbers. ### Built Here First: The Ideas TRT Plus Pioneered URL: https://www.trtplus.app/blog/built-here-first Category: Engineering & Innovation · Published: 2026-07-10 · 6 min read TRT Plus originated a series of TRT app concepts, each on a dated public release: the first app to visualize free testosterone against its bound fractions as a pie chart (April 2023); the Testimator, the first to model individual testosterone response and predict levels across unrun protocols, anchored to the user's own bloodwork and to whether the sample was drawn at peak or trough (May 2023); PTF%, a calculated peak-to-trough fluctuation metric (May 2023); the first closed-loop dose calculator with a syringe diagram (May 2023); the Biomarker Dashboard presenting bloodwork as a scored dashboard (September 2024); enhanced optimization reference ranges built from de-identified real-world TRT clinic data (September 2024); a forward-looking injection rotation planner (November 2024); Zakharov/Mazer/Södergård free-testosterone methods, route-specific multi-route pharmacokinetic models, the coined Clogging Quartet cardiovascular framework, and compound stacking in the syringe (October 2025); and in 2026 the A:E Androgenic Load ratio, a personalized testosterone reference range with a dynamic hematocrit ceiling, the Cardio-Metabolic Cascade, a transdermal saturation model with a cream-to-injectable converter, and a dose titration planner. Built by one developer whose career began drafting pharmaceutical ampoule and vial specifications and continued through two decades of financial-systems engineering. The architecture is a deterministic engine that reasons first, with AI used only for interpretation. Formulas and citations are published on the engine page. ### The Growth Axis: Why Your IGF-1 Range Is Earned, Not Fixed URL: https://www.trtplus.app/blog/the-growth-axis Category: Bloodwork & Scoring · Published: 2026-07-13 · 3 min read The growth axis in the TRT Plus biomarker engine models the sequence estradiol (E2) to growth hormone (GH) to IGF-1, with HbA1c acting as a metabolic gate. Growth hormone has a very short half life, so the engine reads IGF-1 as the stable proxy for the whole axis and never measures GH directly. Estradiol is the enabler: it optimizes the liver's conversion of GH into IGF-1 and activates anabolic signaling pathways, so low E2 can leave IGF-1 low despite adequate testosterone and GH. HbA1c is the gate: good long-term glucose control demonstrates the metabolic headroom to support a higher IGF-1, so the personalized IGF-1 range extends upward, and as control slips the range eases down into a more protective band. HbA1c is assessed on the high side only, so good control earns room while a low reading is a silent positive. The IGF-1 range is earned by metabolic health rather than fixed. No specific numbers or thresholds are given. ## Contact - support@trtplus.app ## License - © TRT Plus. Cite with link to https://www.trtplus.app/